CsiA is a bacterial cell wall synthesis inhibitor contributing to DNA translocation through the cell envelope

1-aminoethylphosphonic acid, an inhibitor of bacterial cell wall synthesis.

Sir: There are numerous steps in bacterial cell wall synthesisll) but the compounds inhibiting this synthesis are limited. To this group of compounds, i. e. penicillins2), cephalosporins2), ristocetin6), vancomycin7), bacillin1^ moenomycin5), prasinomycin9), cycloserine10), O-carbamyl-D-serine10), glycine8), and damino acids3) can be added 1-aminoethylphosphonic acid (AEPA). When titrated again...

The bacterial cell envelope.

C2C12 Cell Line is a Good Model to Explore the Effects of Herbal Extracts on GLUT4 Expression and Translocation

Objective: GLUT4 is a type of glucose transporter and plays a central role in whole-body metabolism of carbohydrates. The muscle is the major site of GLUT4 and cell line models, to explore GLUT4 behaviors under new therapeutic approach, such as herbal components, should be evaluated. Here, C2C12 cell line is evaluated for GLUT4 translocation from intracellular compartment into the cell membrane...

Bacterial cell wall synthesis: the effect of threonine depletion.

Our previous studies of Streptococcus faecalis 9790 have shown that the depletion of an essential amino acid from a highly buffered synthetic medium corresponds to the end of the exponential growth phase (log phase) (2, 3). The end of the log phase is followed by further turbidity changes that are characteristic for the particular amino acid studied. The exhaustion of valine is followed by a sl...

A Burkholderia cenocepacia MurJ (MviN) homolog is essential for cell wall peptidoglycan synthesis and bacterial viability.

The cell wall peptidoglycan (PG) of Burkholderia cenocepacia, an opportunistic pathogen, has not yet been characterized. However, the B. cenocepacia genome contains homologs of genes encoding PG biosynthetic functions in other bacteria. PG biosynthesis involves the formation of the undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-pentapeptide, known as lipid II, whic...